Implantable Tissue-Engineered Cartilage | FUJISOFT Tissue Engineering Co., Ltd
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Implantable Tissue-Engineered Cartilage

World-first product
Development of manufacturing technology for
tissue-engineered steric cartilage

Conventional cartilage repair involves prosthetic joints and autologous transplantation, which are associated with immunological failure of transplanted prosthetic materials and complications related to invasive procedures.
“Implantable tissue-engineered cartilage” is the first in the world and the only steric tissue-engineered medical product derived from patients’ autologous cells. This novel medical technology shows promise in resolving issues associated with conventional cartilage repair and is gathering much attention for its upcoming launch in 2018.

Application in patients with cleft lip/palate nasal deformities

Cleft lip/palate nasal deformity repair used to involve nasal bridge augmentation with a piece of iliac bone, costal cartilage, or skull. However, this repair procedure is associated with difficulties, and advent of a new treatment has been a demand.

Issues with conventional treatment

1. Invasiveness: Collection of a piece of iliac bone, costal cartilage, or skull is invasive and causes pain

2. Hardness: Depends on the hardness of the iliac bone and skull tissue

3. Curvature: Curvature typical of costal cartilage can occur

With the use of implantable tissue-engineered cartilage…
Improve the issues

1. Invasiveness: Significant reduction is possible

2. Hardness: Transplanted cartilage is expected to mature and have a certain level of elasticity

3. Curvature: No curvature-related adverse events have been reported from clinical studies of similar products

Nasal bridge augmentation and maintenance is the objective of this treatment. PLLA mesoporous material is involved in the shape retention immediately after transplanting. Once the cartilage matures, the cartilage matrix synthesized by autologous cells is expected to retain shape of the implant for long-term.

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